In vivo efficacy of a human-simulated regimen of ceftaroline combined with NXL104 against extended-spectrum-beta-lactamase (ESBL)-producing and non-ESBL-producing Enterobacteriaceae.

Abstract

Ceftaroline exhibits in vitro activity against extended-spectrum β-lactamase (ESBL)-, AmpC-, and KPC-producing Enterobacteriaceae when combined with the novel β-lactamase inhibitor NXL104. The purpose of this study was to evaluate the efficacy of a human-simulated regimen of ceftaroline plus NXL104 against Enterobacteriaceae in a murine thigh infection… (More)
DOI: 10.1128/AAC.00024-11

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@article{Wiskirchen2011InVE, title={In vivo efficacy of a human-simulated regimen of ceftaroline combined with NXL104 against extended-spectrum-beta-lactamase (ESBL)-producing and non-ESBL-producing Enterobacteriaceae.}, author={Dora E. Wiskirchen and Jared L. Crandon and Guilherme Henrique Campos Furtado and Gregory Williams and David P Nicolau}, journal={Antimicrobial agents and chemotherapy}, year={2011}, volume={55 7}, pages={3220-5} }