• DOI:10.1016/0091-3057(81)90307-5
Corpus ID: 22221220

In vivo effects of two novel alkylating benzodiazepines, irazepine and kenazepine

@article{Williams1981InVE,
  title={In vivo effects of two novel alkylating benzodiazepines, irazepine and kenazepine},
  author={E. F. Williams and K. Rice and M. Mattson and S. Paul and P. Skolnick},
  journal={Pharmacology Biochemistry and Behavior},
  year={1981},
  volume={14},
  pages={487-491}
}

E. F. Williams, K. Rice, +2 authors P. Skolnick

Published 1981

Chemistry, Medicine

Pharmacology Biochemistry and Behavior

Intracerebroventricular administration of the alkylating benzodiazepines irazepine or kenazepine (20 nmol) resulted in a complete protection against convulsant doses of pentylenetetrazole (PTZ) for at least one hour, and a statistically significant protection for at least two and four hours, respectively. In contrast, administration of the non-alkylating parent benzodiazepine Ro-7/1986 or diazepam (20-60 nmol) resulted in no detectable anticonvulsants effects at fifteen minutes post-injection… CONTINUE READING

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