In vivo effects of insulin-like growth factor-I on the development of sensory pathways: analysis of the primary somatic sensory cortex (S1) of transgenic mice.

@article{GutirrezOspina1996InVE,
  title={In vivo effects of insulin-like growth factor-I on the development of sensory pathways: analysis of the primary somatic sensory cortex (S1) of transgenic mice.},
  author={Gabriel Guti{\'e}rrez-Ospina and Ali Suha Calikoglu and Ping Ye and A Joseph D'ercole},
  journal={Endocrinology},
  year={1996},
  volume={137 12},
  pages={5484-92}
}
In the rodent brain, insulin-like growth factor I (IGF-I) messenger RNA is transiently expressed in sensory projection neurons during periods of synaptogenesis and neuronal growth. Transgenic (Tg) mice with brain IGF-I overexpression and ectopic brain expression of IGF-binding protein-1 (IGFBP-1), an inhibitor of IGF-I actions, show changes in brain size and myelination. We used these mouse models to evaluate in vivo IGF-I effects on sensory pathway development by conducting anatomical studies… CONTINUE READING

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