In vivo effects of insulin and free fatty acids on matrix metalloproteinases in rat aorta.

@article{Boden2008InVE,
  title={In vivo effects of insulin and free fatty acids on matrix metalloproteinases in rat aorta.},
  author={Guenther Boden and Weiwei Song and Laura L. Pashko and Karen Kresge},
  journal={Diabetes},
  year={2008},
  volume={57 2},
  pages={476-83}
}
OBJECTIVE Obesity is associated with insulin resistance, hyperinsulinemia, elevated plasma free fatty acid (FFA), and increased risk for atherosclerotic vascular disease (ASVD). A part of this increased risk may be due to enhanced activation of matrix metalloproteinases (MMPs). Here, we have examined the effects of physiologically elevated levels of insulin and FFA on three MMPs and their inhibitors (tissue inhibitors of MMP [TIMPs]) in aortic tissue of male rats during euglycemic… CONTINUE READING