In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei.

@article{Fairlamb1987InVE,
  title={In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei.},
  author={Alan H. Fairlamb and Gary B. Henderson and Cyrus J. Bacchi and Anthony Cerami},
  journal={Molecular and biochemical parasitology},
  year={1987},
  volume={24 2},
  pages={185-91}
}
The effect of D,L-alpha-difluoromethylornithine (DFMO) on thiol and polyamine levels in Trypanosoma brucei was investigated by isolating trypanosomes from infected rats treated with DFMO for 12-48 h. Concentrations of thiols, polyamines and other amino-compounds were measured by an automated high-performance liquid chromatography method. The levels of DFMO in rat plasma (0.02-1.34 mM) is similar to that found in the parasites (0.27-0.99 mM), concentrations which exceed the Ki of DFMO for T… CONTINUE READING
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