In vivo effects of LR5182, cis-3-(3,4-dichlorophenyl)-2-N,N-dimethylaminomethyl-bicyclo-[2,2,2]-octane hydrochloride, an inhibitor of uptake into dopamine and norepinephrine neurons

@article{Fuller1979InVE,
  title={In vivo effects of LR5182, cis-3-(3,4-dichlorophenyl)-2-N,N-dimethylaminomethyl-bicyclo-[2,2,2]-octane hydrochloride, an inhibitor of uptake into dopamine and norepinephrine neurons},
  author={Ray W. Fuller and Kenneth W. Perry and Harold D. Snoddy},
  journal={Neuropharmacology},
  year={1979},
  volume={18},
  pages={497-501}
}
3 Citations
Chapter 1 Antidepressants
Effects of antidepressant drugs on dopamine uptake and metabolism
  • P. Waldmeier
  • Psychology, Biology
    The Journal of pharmacy and pharmacology
  • 1982
TLDR
The acute effects on D A and NA uptake in vivo and on DA metabolism are reported and the effects of some classical antidepressants and more recently developed drugs on aspects of dopaminergic function under identical conditions are compared.

References

SHOWING 1-10 OF 11 REFERENCES
Blockade of amine depletion by nisoxetine in comparison to other uptake inhibitors.
TLDR
Nisxetine is one of the more potent and specific inhibitors of norepinephrine uptake, differing remarkably from fluoxetine to which it is related structurally.
The effect of tropolone on the formation of 3,4‐dihydroxyphenylacetic acid and 4‐hydroxy‐3‐methoxyphenylacetic acid in the brain of the mouse
TLDR
The results suggest that, in vivo, the formation of 3,4‐dihydroxyphenylacetic acid is not always a simple alternative to the formationof homovanillic acid when the enzyme catechol‐O‐methyl transferase is inhibited.
ANTAGONISM OF CERTAIN EFFECTS OF CATECHOLAMINE-DEPLETING AGENTS BY ANTIDEPRESSANT AND RELATED DRUGS.
TLDR
In terms of potency, protriptyline proved to be the most active antagonist of the several agents studied, both in terms of preventing catecholamine depletion and antagonizing the neuron blocking action of guanethidine.
Comparative effects of pemoline, amfonelic acid and amphetamine on dopamine uptake and release in vitro and on brain 3,4‐dihydroxyphenylacetic acid concentration in spiperone‐treated rats
TLDR
The effects of pemoline, amphetamine and amfonelic add on [3H]dopamine accumulation by rat striatal synaptosomes and on the spiperone-induced elevation OfDOPAC in rat brain are compared.
Biochemical differentiation of amphetamine vs methylphenidate and nomifensine in rats
  • C. Braestrup
  • Biology, Psychology
    The Journal of pharmacy and pharmacology
  • 1977
TLDR
The mechanisms by which the two groups ofhetamine‐like stimulants are differentiated biochemically is discussed with special attention to possible intra‐neuronal inhibition of dopamine oxidation by the ‘(+)‐amphetamine group’.
Actions of amfonelic acid and other non‐amphetamine stimulants on the dopamine neuron *
  • P. A. Shore
  • Biology, Medicine
    The Journal of pharmacy and pharmacology
  • 1976
TLDR
Indomethacin PPP, a PG antagonist, enhanced the responses about 15 to 30% and did not show any antagonistic effects, and it is concluded that the transmitter substance of non-adrenergic inhibitory neurons is neither ATP nor PGs.
...
1
2
...