In vivo effect of insulin to decrease matrix metalloproteinase-2 and -9 activity after arterial injury.


UNLABELLED In vitro, insulin has both growth-promoting and vasculoprotective effects. In vivo, the effect of insulin is mainly protective. Insulin treatment (3 U/day) decreases smooth muscle cell (SMC) migration and neointimal growth after carotid angioplasty in normal rats maintained at normoglycemia by oral glucose. SMC migration requires limited… (More)
DOI: 10.1159/000351611


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