In vivo effect of flucloxacillin in experimental endocarditis caused by mecC-positive staphylococcus aureus showing temperature-dependent susceptibility in vitro.

@article{Mancini2015InVE,
  title={In vivo effect of flucloxacillin in experimental endocarditis caused by mecC-positive staphylococcus aureus showing temperature-dependent susceptibility in vitro.},
  author={Stefano Mancini and Fr{\'e}d{\'e}ric Laurent and Tiago Rafael Veloso and Marlyse Giddey and Jacques Vouillamoz and François Vandenesch and Philippe Moreillon and Jos{\'e} Manuel Entenza},
  journal={Antimicrobial agents and chemotherapy},
  year={2015},
  volume={59 4},
  pages={2435-8}
}
Methicillin-resistant Staphylococcus aureus (MRSA) carrying the mecC gene (mecC-MRSA) exhibited at 37°C MICs of oxacillin close to those of methicillin-susceptible S. aureus (MSSA). We investigated whether at this temperature, mecC-MRSA strains respond to flucloxacillin treatment like MSSA strains, using a rat model of endocarditis. Flucloxacillin (human-like kinetics of 2 g intravenously every 6 h) cured 80 to 100% of aortic vegetations infected with five different mecC-MRSA strains. These… CONTINUE READING
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