In vivo effect of an antilipolytic drug (3,5'-dimethylpyrazole) on autophagic proteolysis and autophagy-related gene expression in rat liver.

@article{Donati2008InVE,
  title={In vivo effect of an antilipolytic drug (3,5'-dimethylpyrazole) on autophagic proteolysis and autophagy-related gene expression in rat liver.},
  author={Alessio Donati and Annamaria Ventruti and Gabriella Cavallini and Matilde Masini and Simona Vittorini and Isabelle Chantret and Patrice Codogno and Ettore Bergamini},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={366 3},
  pages={786-92}
}
Autophagy is an intracellular pathway induced by starvation, inhibited by nutrients, that is responsible for degradation of long-lived proteins and altered cell organelles. This process is involved in cell maintenance could be induced by antilipolytic drugs and may have anti-aging effects [A. Donati, The involvement of macroautophagy in aging and anti-aging interventions, Mol. Aspects Med. 27 (2006) 455-470]. We analyzed the effect of an intraperitoneal injection of an antilipolytic agent (3,5… CONTINUE READING
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