In vivo dynamics of equine infectious anemia viruses emerging during febrile episodes: insertions/duplications at the principal neutralizing domain.

@article{Zheng1997InVD,
  title={In vivo dynamics of equine infectious anemia viruses emerging during febrile episodes: insertions/duplications at the principal neutralizing domain.},
  author={Yao Hu Zheng and Hiroshi Sentsui and Takaaki Nakaya and Yuki Kono and Kazufumi Ikuta},
  journal={Journal of virology},
  year={1997},
  volume={71 7},
  pages={5031-9}
}
Equine infectious anemia virus (EIAV) is a good model for studying mechanisms generating escaped retrovirus variants. We previously sequenced the entire gp90-encoding region of 22 cDNA clones obtained from five antigenically distinct isolates (F1V to F5V) recovered during febrile episodes in horse 493 experimentally infected with the Japanese virulent EIAV strain V70. The results showed that the mutations occurred in the principal neutralizing domain (PND) by insertions/duplications. In this… CONTINUE READING