In vivo dynamic metabolic imaging of obstructive cholestasis in mice.

@article{Li2009InVD,
  title={In vivo dynamic metabolic imaging of obstructive cholestasis in mice.},
  author={F. Li and Yuan Hua Liu and Guan-Tarn Huang and Ling-Ling Chiou and Jhih-Huei Liang and Tzu-Lin Sun and Chen-Yuan Dong and Hsuan-Shu Lee},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2009},
  volume={296 5},
  pages={G1091-7}
}
We tried to image obstructive cholestasis by using a newly developed imaging system to measure the alterations of hepatobiliary function in living mice with their bile ducts ligated. A hepatic imaging window was installed on the upper abdomen soon after the mice underwent ligation of the common bile duct. On the next day, the mice received intravenous injection of rhodamine B isothiocyanate-dextran and carboxyfluorescein diacetate. The later would be transformed into fluorogenic… CONTINUE READING