In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver.

@article{Katoh2007InVD,
  title={In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver.},
  author={Miki Katoh and Toshiro Sawada and Yoshinori Soeno and Miki Nakajima and Chise Tateno and Katsutoshi Yoshizato and Tsuyoshi Yokoi},
  journal={Journal of pharmaceutical sciences},
  year={2007},
  volume={96 2},
  pages={428-37}
}
We previously clarified that major human drug metabolizing enzymes were expressed in a chimeric urokinase-type plasminogen activator (uPA)+/+/severe combined immunodeficient (SCID) mouse line established recently, in which the liver could be replaced by more than 80% with human hepatocytes. In the present study, we investigated the in vivo drug metabolism of a CYP2D6 substrate, debrisoquin (DB), in chimeric mice with high (High) or low (Low) human albumin (hAlb) concentrations and in control… CONTINUE READING
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