In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver.

@article{Katoh2007InVD,
  title={In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver.},
  author={M. Katoh and T. Sawada and Y. Soeno and M. Nakajima and C. Tateno and K. Yoshizato and T. Yokoi},
  journal={Journal of pharmaceutical sciences},
  year={2007},
  volume={96 2},
  pages={
          428-37
        }
}
We previously clarified that major human drug metabolizing enzymes were expressed in a chimeric urokinase-type plasminogen activator (uPA)+/+/severe combined immunodeficient (SCID) mouse line established recently, in which the liver could be replaced by more than 80% with human hepatocytes. In the present study, we investigated the in vivo drug metabolism of a CYP2D6 substrate, debrisoquin (DB), in chimeric mice with high (High) or low (Low) human albumin (hAlb) concentrations and in control… Expand
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