In vivo dopamine clearance rate in rat striatum: regulation by extracellular dopamine concentration and dopamine transporter inhibitors.

@article{Zahniser1999InVD,
  title={In vivo dopamine clearance rate in rat striatum: regulation by extracellular dopamine concentration and dopamine transporter inhibitors.},
  author={Nancy R. Zahniser and Gaynor A Larson and Greg A. Gerhardt},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1999},
  volume={289 1},
  pages={266-77}
}
Dopamine transporter (DAT) inhibitors are expected to decrease dopamine (DA) clearance from the extracellular space of the brain. However, mazindol and cocaine have been reported to "anomalously" increase DA clearance rate. To better understand in vivo DAT activity both in the absence and presence of DAT inhibitors, clearance of exogenously applied DA was measured in dorsal striata of urethane-anesthetized rats using high-speed chronoamperometry. As higher amounts of DA were ejected, DA signal… CONTINUE READING

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inhibitors of the striatal transporter for dopamine

  • JP Ng, SD Menacherry, BJ Liem, D Anderson, M Singer, JB JrJustice
  • J Neurochem
  • 1992
Highly Influential
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