In vivo domain-based functional analysis of the major sporulation sensor kinase, KinA, in Bacillus subtilis.

@article{Eswaramoorthy2009InVD,
  title={In vivo domain-based functional analysis of the major sporulation sensor kinase, KinA, in Bacillus subtilis.},
  author={Prahathees Eswaramoorthy and Tao Guo and Masaya Fujita},
  journal={Journal of bacteriology},
  year={2009},
  volume={191 17},
  pages={5358-68}
}
Sensor histidine kinases are widely used by bacteria to detect and respond to environmental signals. In Bacillus subtilis, KinA is a major kinase providing phosphate input to the phosphorelay that activates the sporulation pathway upon starvation via the phosphorylated Spo0A transcription factor. KinA contains three PAS domains in its amino-terminal sensor domain, which appear to be involved in the sensing of an unidentified sporulation signal(s) produced upon starvation. Prior biochemical… CONTINUE READING