In vivo diffusion tensor imaging and histopathology of the fimbria-fornix in temporal lobe epilepsy.

@article{Concha2010InVD,
  title={In vivo diffusion tensor imaging and histopathology of the fimbria-fornix in temporal lobe epilepsy.},
  author={Luis Concha and Daniel J. Livy and Christian Beaulieu and B. Matt Wheatley and Donald W. Gross},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 3},
  pages={996-1002}
}
While diffusion tensor imaging (DTI) has been extensively used to infer micro-structural characteristics of cerebral white matter in human conditions, correlations between human in vivo DTI and histology have not been performed. Temporal lobe epilepsy (TLE) patients with mesial temporal sclerosis (MTS) have abnormal DTI parameters of the fimbria-fornix (relative to TLE patients without MTS) which are presumed to represent differences in axonal/myelin integrity. Medically intractable TLE… CONTINUE READING