In vivo diagnosis of epidermal growth factor receptor expression using molecular imaging with a cocktail of optically labeled monoclonal antibodies.

@article{Barrett2007InVD,
  title={In vivo diagnosis of epidermal growth factor receptor expression using molecular imaging with a cocktail of optically labeled monoclonal antibodies.},
  author={Tristan Barrett and Yoshinori Koyama and Yukihiro Hama and Gregory Ravizzini and In Soo Shin and Beom-su Jang and Chang H Paik and Yasuteru Urano and Peter L. Choyke and Hisataka Kobayashi},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2007},
  volume={13 22 Pt 1},
  pages={
          6639-48
        }
}
PURPOSE Epidermal growth factor receptors (EGFR) play an important role in tumorigenesis and, therefore, have become targets for new molecular therapies. Here, we use a "cocktail" of optically labeled monoclonal antibodies directed against EGFR-1 (HER1) and EGFR-2 (HER2) to distinguish tumors by their cell surface expression profiles. EXPERIMENTAL DESIGN In vivo imaging experiments were done in tumor-bearing mice following s.c. injection of A431 (overexpressing HER1), NIH3T3/HER2… CONTINUE READING
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