In vivo determination of muscarinic acetylcholine receptor availability in schizophrenia.

@article{Raedler2003InVD,
  title={In vivo determination of muscarinic acetylcholine receptor availability in schizophrenia.},
  author={Thomas J. Raedler and Michael B. Knable and Douglas W. Jones and Richard A Urbina and Julia G. Gorey and Kan Sam Lee and Michael Egan and Richard Coppola and Daniel R. Weinberger},
  journal={The American journal of psychiatry},
  year={2003},
  volume={160 1},
  pages={
          118-27
        }
}
OBJECTIVE Postmortem studies have implicated the central muscarinic acetylcholine system in schizophrenia. However, central muscarinic receptor availability has not previously been studied in vivo. Using [I-123]iodoquinuclidinyl benzilate ([(123)I]IQNB) single photon emission computed tomography (SPECT), the authors sought to compare the muscarinic receptor availability in vivo in unmedicated patients with schizophrenia and normal subjects. METHOD Twelve medication-free patients with… 
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References

SHOWING 1-10 OF 63 REFERENCES

Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [123I]β-CIT

The distribution of cerebral muscarinic acetylcholine receptors in vivo in patients with dementia. A controlled study with 123IQNB and single photon emission computed tomography.

The data suggest that focal abnormalities in muscarinic binding in vivo may characterize some patients with Alzheimer's disease and Pick's disease, but further studies are needed to address questions about partial volume artifacts and receptor quantification.

In Vivo Olanzapine Occupancy of Muscarinic Acetylcholine Receptors in Patients with Schizophrenia

D2 dopamine receptors in neuroleptic-naive schizophrenic patients. A positron emission tomography study with [11C]raclopride.

The hypothesis of generally elevated central D2 dopamine receptor densities in schizophrenia was not supported by the present findings, and significantly higher densities were found in the left than in the right putamen but not in the caudate nucleus.

Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics.

Schizophrenia itself is associated with an increase in brain D2 dopamine receptor density, and the densities in the caudate nucleus were higher in both groups of patients than in the normal volunteers.

The density of muscarinic M1 receptors is decreased in the caudate-putamen of subjects with schizophrenia.

The density of M1 receptors was decreased in the caudate-putamen from the schizophrenic subjects and this data raise the possibility that changes in muscarinic receptors may be involved in the pathology of schizophrenia.

Decreased muscarinic receptor binding in subjects with schizophrenia: a study of the human hippocampal formation

The binding of [3H]AF-DX 384 is reduced in the caudate-putamen of subjects with schizophrenia.

Altered dopaminergic function and negative symptoms in drug-free patients with schizophrenia

Worsening of negative symptoms may be associated with increased availability of striatal D2 receptors, perhaps because of decreased concentrations of endogenous dopamine.

Striatal dopamine transporter binding in neuroleptic-naive patients with schizophrenia studied with positron emission tomography.

Average striatal dopamine transporter density is unaltered in neuroleptic-naive patients with schizophrenia, however, patients lack asymmetry in caudate dopamine transporter binding, which conforms with disrupted brain lateralization in this disorder.
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