In vivo detection of thalamic gliosis: a pathoradiologic demonstration in familial fatal insomnia.

@article{Hak2008InVD,
  title={In vivo detection of thalamic gliosis: a pathoradiologic demonstration in familial fatal insomnia.},
  author={St{\'e}phane Ha{\"i}k and Damien Galanaud and Marius George Linguraru and Katell H Peoc'h and Nicolas Privat and Baptiste Faucheux and Nicholas Ayache and J. J. Hauw and Didier Dormont and Jean-Philippe Brandel},
  journal={Archives of neurology},
  year={2008},
  volume={65 4},
  pages={545-9}
}
BACKGROUND Increasing evidence supports the usefulness of brain magnetic resonance imaging (MRI) for the diagnosis of human prion diseases. From the neuroradiological point of view, fatal familial insomnia is probably the most challenging to diagnose because brain lesions are mostly confined to the thalamus. OBJECTIVE To determine whether multisequence MRI of the brain can show thalamic alterations and establish pathoradiologic correlations in a patient with familial fatal insomnia. DESIGN… CONTINUE READING

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Compassionate use of quinacrine in CreutzfeldtJakob disease fails to show significant effects. Neurology

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