In vivo detection of single cells by MRI.

  title={In vivo detection of single cells by MRI.},
  author={Erik M. Shapiro and Kathryn Sharer and Stanko Skrtic and Alan P. Koretsky},
  journal={Magnetic resonance in medicine},
  volume={55 2},
The use of high-relaxivity, intracellular contrast agents has enabled MRI monitoring of cell migration through and homing to various tissues, such as brain, spinal cord, heart, and muscle. Here it is shown that MRI can detect single cells in vivo, homing to tissue, following cell labeling and transplantation. Primary mouse hepatocytes were double-labeled with green fluorescent 1.63-microm iron oxide particles and red fluorescent endosomal labeling dye, and injected into the spleens of recipient… CONTINUE READING
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