In vivo detection of nitric oxide distribution in mice

  title={In vivo detection of nitric oxide distribution in mice},
  author={Andrei M. Komarov},
  journal={Molecular and Cellular Biochemistry},
This paper discusses in vivo detection of nitric oxide (NO) distribution in endotoxin-treated mice using L-band (1.1 GHz) electron paramagnetic resonance spectroscopy (EPR) in combination with the hydrophilic NO trapping complex: N-methyl-D-glucamine dithiocarbamate and iron (MGD-Fe). MGD-Fe-NO complex is found in the upper abdomen (liver region), lower abdomen (kidney and urinary bladder) and head region of ICR mice. Experiments with nitric oxide synthase (NOS) inhibition and 15N-labeled L… CONTINUE READING

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