In vivo detection limits of magnetically labeled embryonic stem cells in the rat brain using high-field (17.6 T) magnetic resonance imaging.

@article{Stroh2005InVD,
  title={In vivo detection limits of magnetically labeled embryonic stem cells in the rat brain using high-field (17.6 T) magnetic resonance imaging.},
  author={Albrecht Stroh and Cornelius Faber and Thomas Neuberger and Peer Lorenz and Katharina Sieland and Peter M. Jakob and Andrew Webb and Herbert Pilgrimm and Ralf Schober and Elena E. Pohl and Claus Zimmer},
  journal={NeuroImage},
  year={2005},
  volume={24 3},
  pages={635-45}
}
Stem cell transplantation is a promising therapeutic approach for several neurological disorders. However, it has yet to fulfill its high expectations, partially due to the lack of a reliable noninvasive method for monitoring the biodistribution of the grafted stem cells in vivo. We have used high-resolution magnetic resonance imaging (MRI) at 17.6 T, combined with efficient magnetic labeling of the stem cells with iron oxide nanoparticles, in order to assess the in vivo detection limit in… CONTINUE READING
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