In vivo detection and partial characterization of effector and suppressor cell populations in spleens of mice with large metastatic fibrosarcomas.

@article{Dent1985InVD,
  title={In vivo detection and partial characterization of effector and suppressor cell populations in spleens of mice with large metastatic fibrosarcomas.},
  author={Lindsay A Dent and John J. Finlay-Jones},
  journal={British Journal of Cancer},
  year={1985},
  volume={51},
  pages={533 - 541}
}
  • Lindsay A Dent, John J. Finlay-Jones
  • Published in British Journal of Cancer 1985
  • Medicine, Biology
  • The MC-2 fibrosarcoma, which is a transplantable tumour syngeneic for BALB/c mice, metastasizes to lymph nodes draining subcutaneous inoculation sites, and also to the lungs. T cell-mediated immunity was detected in Winn assays using spleens from excision immunized mice. T cell-mediated anti-tumour immunity was also detected in spleens from mice with small tumours but disappeared as the tumour burden increased. Protective immune spleen cell activity in the Winn assay was inhibited by prior… CONTINUE READING

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