In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion.

@article{Ianus2003InVD,
  title={In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion.},
  author={Andreea Ianus and George G. Holz and Neil D. Theise and Mehboob Ali Hussain},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={111 6},
  pages={843-50}
}
Bone marrow harbors cells that have the capacity to differentiate into cells of nonhematopoietic tissues of neuronal, endothelial, epithelial, and muscular phenotype. Here we demonstrate that bone marrow-derived cells populate pancreatic islets of Langerhans. Bone marrow cells from male mice that express, using a CRE-LoxP system, an enhanced green fluorescent protein (EGFP) if the insulin gene is actively transcribed were transplanted into lethally irradiated recipient female mice. Four to six… CONTINUE READING
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