In vivo depletion of CD11c+ cells impairs scrapie agent neuroinvasion from the intestine.

@article{Raymond2007InVD,
  title={In vivo depletion of CD11c+ cells impairs scrapie agent neuroinvasion from the intestine.},
  author={Claudine R. Raymond and P. Aucouturier and Neil A Mabbott},
  journal={Journal of immunology},
  year={2007},
  volume={179 11},
  pages={7758-66}
}
Following oral exposure, some transmissible spongiform encephalopathy (TSE) agents accumulate first upon follicular dendritic cells (DCs) in the GALT. Studies in mice have shown that TSE agent accumulation in the GALT, in particular the Peyer's patches, is obligatory for the efficient transmission of disease to the brain. However, the mechanism through which TSE agents are initially conveyed from the gut lumen to the GALT is not known. Studies have implicated migratory hemopoietic DCs in this… CONTINUE READING

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