In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice.

@article{WescheSoldato2005InVD,
  title={In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice.},
  author={Doreen E. Wesche-Soldato and Chun-Shiang Chung and Joanne L. Lomas-Neira and Lesley A. Doughty and Stephen H. Gregory and Alfred Ayala},
  journal={Blood},
  year={2005},
  volume={106 7},
  pages={2295-301}
}
Although studies have shown increased evidence of death receptor-driven apoptosis in intestinal lymphoid cells, splenocytes, and the liver following the onset of polymicrobial sepsis, little is known about the mediators controlling this process or their pathologic contribution. We therefore attempted to test the hypothesis that the hydrodynamic administration of small interfering RNA (siRNA) against the death receptor, Fas or caspase-8, should attenuate the onset of morbidity and mortality seen… CONTINUE READING

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In vivo delivery of caspase 8 siRNA improves the survival of septic mice

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