In vivo covalent binding of trans-4-hydroxy-2-hexenal to rat liver macromolecules.

@article{Grasse1985InVC,
  title={In vivo covalent binding of trans-4-hydroxy-2-hexenal to rat liver macromolecules.},
  author={L D Grasse and Michael W. Lam{\'e} and Henry J Segall},
  journal={Toxicology letters},
  year={1985},
  volume={29 1},
  pages={43-9}
}
Trans-4-hydroxy-2-hexenal (t-4HH), a metabolite isolated from the macrocyclic pyrrolizidine alkaloid senecionine, was tritiated to perform in vivo covalent binding studies. The in vivo binding of [3H]t-4HH to rat liver DNA, RNA and protein was investigated. No significant binding to hepatic DNA or RNA could be detected, but levels of 429 +/- 139 pmol/mg were found covalently bound to hepatic proteins 16 h after exposure. Levels as high as 916 pmol/mg protein were detected 2 h after… CONTINUE READING

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