In vivo conversion of gamma-aminobutyric acid and 1,4-butanediol to gamma-hydroxybutyric acid in rat brain. Studies using stable isotopes.

@article{Snead1989InVC,
  title={In vivo conversion of gamma-aminobutyric acid and 1,4-butanediol to gamma-hydroxybutyric acid in rat brain. Studies using stable isotopes.},
  author={O. C. Snead and Raymond L. Furner and Chun Che Liu},
  journal={Biochemical pharmacology},
  year={1989},
  volume={38 24},
  pages={4375-80}
}
The formation of 4-[1,4-13C]hydroxybutyric acid ([13C]gamma-hydroxybutyric acid; [13C]GHB) in rat brain was studied following intracerebroventricular (i.c.v.) administration of either 4-[1,4-13C]aminobutyric acid ([13C]GABA or 1,4-[1,4-13C]butanediol ([13C]1,4-BD) to awake, freely moving animals. GHB and [13C]GHB were measured with a gas chromatographic mass spectrometric (GC/MS) technique designed to detect the lactone derivative of GHB with the acid or lactone being determined by conditions… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Gamma hydroxybutyric acid (GHB) intoxication.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine • 2002
View 5 Excerpts
Highly Influenced

GHB, GBL and 1,4-BD addiction.

Current pharmaceutical design • 2014
View 1 Excerpt

Extrasynaptic site of action for γ-hydroxybutyrate.

Proceedings of the National Academy of Sciences of the United States of America • 2012
View 2 Excerpts

Similar Papers

Loading similar papers…