In vivo conversion of astrocytes to myelinating cells by miR-302/367 and valproate to enhance myelin repair.

@article{GhasemiKasman2018InVC,
  title={In vivo conversion of astrocytes to myelinating cells by miR-302/367 and valproate to enhance myelin repair.},
  author={Maryam Ghasemi-Kasman and L Hamidpour Zare and Hossein Baharvand and Mohammad R. Javan},
  journal={Journal of tissue engineering and regenerative medicine},
  year={2018},
  volume={12 1},
  pages={
          e462-e472
        }
}
Enhancement of repair potential for degenerative brain diseases has been a research priority during recent years. Considering recent advancements in the field of direct transdifferentiation, conversion of astrocytes as a prominent component of glial scars to the progenitor cells that contribute to the repair mechanisms seems interesting. Recently, we have reported miR-302/367-mediated in vivo conversion of astrocytes into neuroblasts and neurons. In the current study, we used miR-302/367 and… CONTINUE READING
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