In vivo controlled release of PGE2 from a vaginal insert (0.8 mm, 10 mg) during induction of labour

@article{Lyrens2001InVC,
  title={In vivo controlled release of PGE2 from a vaginal insert (0.8 mm, 10 mg) during induction of labour},
  author={Sven Lyren{\"a}s and I Clason and Ulf Ulmsten},
  journal={BJOG: An International Journal of Obstetrics \& Gynaecology},
  year={2001},
  volume={108}
}
Objective To measure the release rate of prostaglandin E2 (PGE2) in vivo from a controlled‐release vaginal insert used for cervical ripening and induction of labour at term in women with intact membranes or pre‐labour rupture of membranes (PROM). 

Paper Mentions

Interventional Clinical Trial
The aim of this study is to compare two different preparation  
ConditionsCervical Ripening, Labor, Induced
InterventionDrug
Controlled-release dinoprostone vaginal insert for cervical ripening and labor induction
TLDR
A proprietary sustained- and controlled-release dinoprostone vaginal insert has been shown to decrease the time to vaginal delivery compared with placebo and provides safe and efficacious cervical ripening in women with an unfavorable cervix. Expand
Cervical ripening and induction of labor by prostaglandin E2: a comparison between intracervical gel and vaginal pessary
  • G. D'aniello, C. Bocchi, +7 authors F. Petraglia
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2003
TLDR
Both PGE2 administration routes appeared to be effective in achieving cervical ripening, initiation of labor and optimal type of delivery, and showed the same incidence of side-effects. Expand
Randomized trial of vaginal prostaglandin E2 versus oxytocin for labor induction in term premature rupture of membranes.
TLDR
Oxytocin treatment seems to be superior to vaginal administration of PGE(2) to induce labor in term pregnancies complicated with PROM and unfavorable services. Expand
Comparison of prostaglandin E2 tablets or Foley catheter for labour induction in grand multiparas.
  • M. Al-Taani
  • Medicine
  • Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
  • 2004
TLDR
For grand multiparas, PGE2 vaginal tablets may be preferable for ripening the cervix as well as for labour induction, and time from induction to delivery was significantly shorter in the P GE2 group than the Foley catheter group. Expand
Pre-induction cervical ripening: comparing between two vaginal preparations of dinoprostone in women with an unfavorable cervix
  • E. Ashwal, L. Hiersch, +4 authors Y. Yogev
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2014
TLDR
Slow-release P GE2 vaginal insert achieves cervical ripening and subsequently delivery over a shorter time period than PGE2 tablets, without increasing uterine hyperstimulation rate. Expand
Comparison of prostaglandin E2 tablets or Foley catheter for labour induction in grand multiparas.
TLDR
For grand multiparas, PGE 2 vaginal tablets may be preferable for ripening the cervix as well as for labour induction, and time from induction to delivery was significantly shorter in the PGE2 group than the catheter group. Expand
A prospective study for the effect of vaginal ph on dinoprostone gel for cervical ripening / labor induction
TLDR
Assessing vaginal pH before induction can be an useful parameter in predicting the outcome of labour in pregnant women who are undergoing labour induction with PGE2 gel and further research with a well designed pharmacological study with bigger study population is necessary. Expand
A clinical evaluation of controlled-release dinoprostone for cervical ripening – a review of current evidence in hospital and outpatient settings
  • W. Rath
  • Medicine
  • Journal of perinatal medicine
  • 2005
TLDR
The ease of use of controlled-release dinoprostone and women's satisfaction emphasize its benefits over many other agents used to ripen the cervix, and the efficacy and safety are comparable whether it is used in the outpatient or the inpatient setting. Expand
Impact of prolonged dinoprostone cervical ripening on the rate of artificial induction of labor: A prospective study of 330 patients
The aim of this study was to evaluate two regimens of administration of sustained‐release dinoprostone on the need for oxytocin induction of labor.
Dinoprostone Vaginal Insert: A Review in Cervical Ripening
TLDR
The demonstrated effectiveness and safety of the device, combined with the benefits of controlled drug release from a simple, single application, and efficient dose control, suggest that dinoprostone vaginal insert is a valuable option for promoting cervical ripening in patients with an unfavourable cervix at term. Expand
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References

SHOWING 1-10 OF 35 REFERENCES
Local administration of prostaglandin E2 for cervical ripening and labor induction: the appropriate route and dose
TLDR
The safety, efficacy and the appropriate route and dose of the gel are still debated and there are many comparative studies concerning the local administration of prostaglandin E2 gel for cervical ripening and labor induction. Expand
Induction of labour with a sustained-release prostaglandin E2 vaginal pessary.
TLDR
A new polymer vaginal pessary providing sustained constant release of prostaglandin E2 was administered to 66 patients before planned induction of labour and it is an important step in the development of non-invasive methods of inducing labour. Expand
Inducing labor with a sustained-release PGE2 vaginal insert. Experience at a community hospital.
TLDR
This PGE2 vaginal insert, administered and removed by attending nurses, is associated with very low rates of uterine hyperstimulation and failed induction. Expand
EXTRA‐AMNIOTIC PROSTAGLANDIN E2 FOR THE INDUCTION OF LABOUR AT TERM
Prostaglandin E2 was administered by continuous extra‐amniotic infusion to induce labour in 40 patients between 38 and 42 weeks' gestation. Induction was successful in all cases. The meanExpand
The concurrent in vitro and in vivo release of PGE2 from a controlled-release hydrogel polymer pessary for cervical ripening.
TLDR
The results show that PGE2 release from the pessaries in vivo is predictable, and suggest that the controlled release pessary offers the advantages of greater control of cervical ripening than alternative vehicles currently available. Expand
Prostaglandin metabolite levels during cervical ripening with a controlled-release hydrogel polymer prostaglandin E2 pessary.
TLDR
The results suggest that PGE2 released by the pessary crosses the vaginal epithelium and may stimulate endogenous prostaglandin production, suggesting that it should provide greater control in labour induction than other vehicles studied. Expand
Randomised trial of one versus two doses of prostaglandin E2 for induction of labour: 1. Clinical outcome
TLDR
The outcome of induction of labour using a single versus two doses of prostaglandin E2 vaginal gel is compared to determine whether or not to use a second dose. Expand
The effect of pH on release of PGE2 from vaginal and endocervical preparations for induction of labor: An in vitro study
TLDR
The results suggest that vaginal pH could influence PGE2 release and this may result in variable clinical responses, and pH should be taken into account in the development of preparations for clinical use. Expand
Improved intravaginal controlled-release prostaglandin E2 insert for cervical ripening at term. The Prostaglandin E2 insert Study Group.
TLDR
In conclusion, when administered in a controlled-release vaginal insert with a retrieval system, PGE2 is effective in promoting cervical ripening at term. Expand
A randomized clinical trial of prostaglandin E2 intracervical gel and a slow release vaginal pessary for preinduction cervical ripening.
TLDR
Preinduction cervical ripening with a slow release prostaglandin E2 vaginal pessary resulted in greater change in Bishop score than with intracervical prostaglanders E2, and there was a trend toward shorter time to delivery with the pessaries. Expand
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