In vivo combination of misonidazole and the chemotherapeutic agent CCNU.

@article{Siemann1981InVC,
  title={In vivo combination of misonidazole and the chemotherapeutic agent CCNU.},
  author={Dietmar W. Siemann},
  journal={British Journal of Cancer},
  year={1981},
  volume={43},
  pages={367 - 377}
}
The response of intramuscularly growing KHT sarcomas to the chemotherapeutic agent (1-(2-cloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) alone or simultaneously with the chemical radio-sensitizer misonidazole (MISO) was assessed using either a tumour growth-delay assay or an in vivo-in vitro tumour-excision assay. Median tumour growth delay following the combination of 20 mg/kg CCNU and either 0.5 or 1.0 mg/g MISO was 19.5 and 21.5 days, compared to 10 days for this CCNU dose alone. A similar… CONTINUE READING
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