In vivo clonogenic tumor cell kinetics following 1,3-bis(2-chloroethyl)-1-nitrosourea brain tumor therapy.

@article{Rosenblum1976InVC,
  title={In vivo clonogenic tumor cell kinetics following 1,3-bis(2-chloroethyl)-1-nitrosourea brain tumor therapy.},
  author={MarkL. Rosenblum and Kathy D. Knebel and Dr. Albert Vasquez and CharlesB. Wilson},
  journal={Cancer research},
  year={1976},
  volume={36 10},
  pages={
          3718-25
        }
}
An in vitro colony formation assay was modified to determine the effects of in vivo 1,3-bis(2-chloroethyl)-1-nitrosourea therapy on tumor cell kill and subsequent clonogenic cell kinetics. The measured surviving fraction must be multiplied by the relative total number of tumor cells for each posttreatment interval in order to eliminate inaccuracies caused by dead cell removal in vivo and the lysis of damaged cells by the disaggregation procedure. The assumptions, limitations, and applications… CONTINUE READING

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