In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration.

@article{Rinkevich2014InVC,
  title={In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration.},
  author={Yuval Rinkevich and Daniel T. Montoro and Humberto Contreras-Trujillo and Orit Harari-Steinberg and Aaron M. Newman and Jonathan Tsai and Xinhong Lim and Renee Van-Amerongen and Angela N Bowman and Michael Januszyk and Oren Pleniceanu and Roeland Nusse and Michael Thornton Longaker and Irving L Weissman and Benjamin Dekel},
  journal={Cell reports},
  year={2014},
  volume={7 4},
  pages={1270-83}
}
The mechanism and magnitude by which the mammalian kidney generates and maintains its proximal tubules, distal tubules, and collecting ducts remain controversial. Here, we use long-term in vivo genetic lineage tracing and clonal analysis of individual cells from kidneys undergoing development, maintenance, and regeneration. We show that the adult mammalian kidney undergoes continuous tubulogenesis via expansions of fate-restricted clones. Kidneys recovering from damage undergo tubulogenesis… CONTINUE READING
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Identification and prospective isolation of a mesothelial precursor lineagegiving rise to smoothmusclecells andfibroblasts formammalian internal organs, and their vasculature

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