In vivo characterization of changing blood-tumor barrier permeability in a mouse model of breast cancer metastasis: a complementary magnetic resonance imaging approach.

@article{Percy2011InVC,
  title={In vivo characterization of changing blood-tumor barrier permeability in a mouse model of breast cancer metastasis: a complementary magnetic resonance imaging approach.},
  author={Dean B Percy and Emeline J. Ribot and Yuhua Chen and Catherine McFadden and Carmen Simedrea and Patricia S. Steeg and Ann F. Chambers and Paula J. Gareau Foster},
  journal={Investigative radiology},
  year={2011},
  volume={46 11},
  pages={718-25}
}
OBJECTIVES The current lack of efficacy for any chemo- or molecular therapeutic in the treatment of brain metastases is thought to be due, in part, to the heterogeneous permeability of the blood-brain-barrier (BBB). Little is known about how heterogeneous permeability develops, or how it varies among individual metastases. Understanding the BBB's role in metastasis will be crucial to the development of new, more effective therapies. In this article, we developed the first magnetic resonance… CONTINUE READING