In vivo characterization of MMP-2200, a mixed δ/μ opioid agonist, in mice.

@article{Lowery2011InVC,
  title={In vivo characterization of MMP-2200, a mixed δ/μ opioid agonist, in mice.},
  author={John J. Lowery and Tyler J. Raymond and Denise Giuvelis and Jean M Bidlack and Robin Polt and Edward J. Bilsky},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2011},
  volume={336 3},
  pages={767-78}
}
We have previously reported the chemistry and antinociceptive properties of a series of glycosylated enkephalin analogs (glycopeptides) exhibiting approximately equal affinity and efficacy at δ opioid receptors (DORs) and μ opioid receptors (MORs). More detailed pharmacology of the lead glycopeptide MMP-2200 [H₂N-Tyr-D-Thr-Gly-Phe-Leu-Ser-(O-β-D-lactose)-CONH₂] is presented. MMP-2200 produced dose-related antinociception in the 55°C tail-flick assay after various routes of administration. The… CONTINUE READING