In vivo characterisation of a novel water-soluble Cyclosporine A prodrug for the treatment of dry eye disease.

Abstract

Cyclosporine A (CsA) has been demonstrated to be effective for the treatment of a variety of ophthalmological conditions, including ocular surface disorders such as the dry eye disease (DED). Since CsA is characterised by its low water solubility, the development of a topical ophthalmic formulation represents an interesting pharmaceutical question. In the… (More)
DOI: 10.1016/j.ejpb.2011.11.017

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@article{RodriguezAller2012InVC, title={In vivo characterisation of a novel water-soluble Cyclosporine A prodrug for the treatment of dry eye disease.}, author={Marta Rodriguez-Aller and B{\'e}atrice Kaufmann and Davy Guillarme and Cinzia Stella and Pascal Furrer and Serge Rudaz and Ikram El Zaoui and Fatemeh Valamanesh and Claudia Di Tommaso and Francine B{\'e}har-Cohen and J. - L. Veuthey and Robert Gurny}, journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V}, year={2012}, volume={80 3}, pages={544-52} }