In vivo characterisation of a novel water-soluble Cyclosporine A prodrug for the treatment of dry eye disease.

@article{RodriguezAller2012InVC,
  title={In vivo characterisation of a novel water-soluble Cyclosporine A prodrug for the treatment of dry eye disease.},
  author={Marta Rodriguez-Aller and B{\'e}atrice Kaufmann and Davy Guillarme and Cinzia Stella and Pascal Furrer and Serge L. Rudaz and Ikram El Zaoui and Fatemeh Valamanesh and Claudia Di Tommaso and Francine B{\'e}har-Cohen and J L Veuthey and Robert Gurny},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2012},
  volume={80 3},
  pages={544-52}
}
Cyclosporine A (CsA) has been demonstrated to be effective for the treatment of a variety of ophthalmological conditions, including ocular surface disorders such as the dry eye disease (DED). Since CsA is characterised by its low water solubility, the development of a topical ophthalmic formulation represents an interesting pharmaceutical question. In the present study, two different strategies to address this challenge were studied and compared: (i) a water-soluble CsA prodrug formulated… CONTINUE READING
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