In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS

@article{Lossi2003InVC,
  title={In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS},
  author={Laura Lossi and Adalberto Merighi},
  journal={Progress in Neurobiology},
  year={2003},
  volume={69},
  pages={287-312}
}
View on Elsevier
doi.org
155 Citations
Highly Influential Citations
1
Background Citations
70
Methods Citations
2

155 Citations

Citation Type

Citation Type

Molecular morphology of neuronal apoptosis: Analysis of caspase 3 activation during postnatal development of mouse cerebellar cortex
TLDR
Data obtained from cerebellar cortex can be generalized to outline a more comprehensive picture of the cellular and molecular mechanisms of neuronal death not only in development, but also in a number of pathological conditions leading to neuronal loss.
Neuronal cell death: an overview of its different forms in central and peripheral neurons.
TLDR
The main histological and ultrastructural features of the different types of cell death in neurons are described and related to the cellular pathways that are specifically activated in any of these types of PCD.
Apoptosis of the cerebellar neurons.
TLDR
This review examines the existing evidence about the two waves of apoptotic cell death that affect the different types of cerebellar neurons in normal development and certain pathological conditions.
Caspase-3 Mediated Cell Death in the Normal Development of the Mammalian Cerebellum
TLDR
Among the different types of neurons and glia in cerebellum, there is ample evidence for an intervention of caspase-3 in the regulation of NOND of the post-mitotic cerebellar granule cells and Purkinje neurons, as a consequence of failure to establish proper synaptic contacts with target (secondary cell death).
Cell death in early neural life.
TLDR
Observations on cell death in the early, proliferating stages of vertebrate neural development in mice and complementary in vivo approaches in other vertebrates are covered.
Essential Role for Survivin in Early Brain Development
TLDR
This study is the first to solidify a role for survivin as an antiapoptotic protein during normal neuronal development in vivo, and may impact on the understanding of neural repair, neural development, and neurodegenerative diseases.
Apoptosis: a key in neurodegenerative disorders.
TLDR
Current concepts salient to understanding the apoptosis death program, the mediators and control of cellular apoptosis, and the relationship between aberrant apoptosis and genesis of neurodegenerative disorders are focused on.
Apoptosis in the central nervous system: Mechanisms and protective strategies.
  • M. Kajta
  • Biology
    Polish journal of pharmacology
  • 2004
TLDR
Defining molecular mechanisms of programmed cell death is the necessary step preceding the adaptation of new protective and then, possibly, therapeutic strategies, and at present, the most promising are discoveries related to caspases, JNK, and GSK-3beta and their crucial role in stress-dependent and spontaneous apoptosis.
Neuronal survival in the brain: neuron type-specific mechanisms
TLDR
This review focuses on how immature neurons survive during normal and impaired brain development, both in the embryonic/neonatal brain and in brain regions associated with adult neurogenesis, and emphasizes neuron type-specific mechanisms that help to survive for various types of immature neurons.
Cell death and neurodegeneration in the postnatal development of cerebellar vermis in normal and Reeler mice.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 270 REFERENCES
Neuronal death in the central nervous system during development.
The role of cell death in regulating the size and shape of the mammalian forebrain.
TLDR
The precise coordination of different apoptotic signaling pathways during early stages of neurogenesis is crucial for regulation of the proper cortical size and shape.
The role of free radicals and p53 in neuron apoptosis in vivo
  • K. A. Wood, R. Youle
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
TLDR
It is demonstrated that ionizing radiation induces extensive cerebellar granule cell death via apoptosis in vivo, and the extensive death of cerebellary granule cells induced by methylazoxymethanol was found to be independent of the DNA fragmentation characteristic of apoptosis, and was also independent of expression of p53.
In Vivo Analysis of Cell Proliferation and Apoptosis in the CNS
TLDR
Analysis of cell proliferation and apoptosis in vivo has recently gained an increasing importance mainly considering that proliferative and/or apoptotic events have been extensively characterized not only during embryonic development but also in several areas of the postnatal and adult brain.
Apoptosis and the Nervous System
TLDR
It appears certain that the Bcl family of proteins is involved in the apoptotic pathway, and these proteins in turn affect the processing of interleukin‐1β converting enzyme (ICE)/caspases.
In vivo analysis reveals different apoptotic pathways in pre- and postmigratory cerebellar granule cells of rabbit.
TLDR
It is concluded that NOND of premigratory CGCs is linked to activation of DNA checkpoint and alteration of normal cell cycle, whereas in postmigratoryCGCs apoptosis is, more classically, dependent upon caspase 3 activation.
Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex.
TLDR
Surprisingly, while dying cells were observed throughout the cerebral cortical wall, the majority were found within zones of cell proliferation rather than in regions of postmitotic neurons, suggesting that multiple mechanisms may regulate programmed cell death in the developing cortex.
Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases
TLDR
Results are consistent with the growing idea that the involvement of specific caspases and the occurrence of caspase-independent programmed cell death may be dependent on brain region, cell type, age, and species or may be the result of specific perturbations or pathology.
Physiological and induced neuronal death are not affected in NSE‐bax transgenic mice
TLDR
In the model system, Bax overexpression did not appear to influence the in vitro survival of sensory neurons isolated from dorsal root ganglia after nerve grwoth factor (NFG) deprivation or the apoptotic death of motor neurons following axotomy.
Apoptosis and Its Relation to the Cell Cycle in the Developing Cerebral Cortex
TLDR
It is concluded that apoptosis is prominent in the proliferating neuroepithelium of the developing rat cerebral cortex and that it is related to the progression of the cell cycle.
...
1
2
3
4
5
...