In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS

@article{Lossi2003InVC,
  title={In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS},
  author={Laura Lossi and Adalberto Merighi},
  journal={Progress in Neurobiology},
  year={2003},
  volume={69},
  pages={287-312}
}
Apoptosis has been recognized to be an essential process during neural development. It is generally assumed that about half of the neurons produced during neurogenesis die before completion of the central nervous system (CNS) maturation, and this process affects nearly all classes of neurons. In this review, we discuss the experimental data in vivo on naturally occurring neuronal death in normal, transgenic and mutant animals, with special attention to the cerebellum as a study model. The… 
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References

SHOWING 1-10 OF 270 REFERENCES
Neuronal death in the central nervous system during development.
TLDR
The experiments on retinal ganglion cells indicate that several apoptotic mechanisms apply in this particular in vivo situation: these include an involvement of oxygenated free radicals and glutathione, cell cycle-related events, and probably the synthesis of proteins promoting neuroprotection or cell death.
The role of cell death in regulating the size and shape of the mammalian forebrain.
TLDR
The precise coordination of different apoptotic signaling pathways during early stages of neurogenesis is crucial for regulation of the proper cortical size and shape.
The role of free radicals and p53 in neuron apoptosis in vivo
  • K. A. Wood, R. Youle
  • Biology, Medicine
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
TLDR
It is demonstrated that ionizing radiation induces extensive cerebellar granule cell death via apoptosis in vivo, and the extensive death of cerebellary granule cells induced by methylazoxymethanol was found to be independent of the DNA fragmentation characteristic of apoptosis, and was also independent of expression of p53.
In Vivo Analysis of Cell Proliferation and Apoptosis in the CNS
TLDR
Analysis of cell proliferation and apoptosis in vivo has recently gained an increasing importance mainly considering that proliferative and/or apoptotic events have been extensively characterized not only during embryonic development but also in several areas of the postnatal and adult brain.
In vivo analysis reveals different apoptotic pathways in pre- and postmigratory cerebellar granule cells of rabbit.
TLDR
It is concluded that NOND of premigratory CGCs is linked to activation of DNA checkpoint and alteration of normal cell cycle, whereas in postmigratoryCGCs apoptosis is, more classically, dependent upon caspase 3 activation.
Apoptosis and the Nervous System
TLDR
It appears certain that the Bcl family of proteins is involved in the apoptotic pathway, and these proteins in turn affect the processing of interleukin‐1β converting enzyme (ICE)/caspases.
Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex.
TLDR
Surprisingly, while dying cells were observed throughout the cerebral cortical wall, the majority were found within zones of cell proliferation rather than in regions of postmitotic neurons, suggesting that multiple mechanisms may regulate programmed cell death in the developing cortex.
Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases
TLDR
Results are consistent with the growing idea that the involvement of specific caspases and the occurrence of caspase-independent programmed cell death may be dependent on brain region, cell type, age, and species or may be the result of specific perturbations or pathology.
Physiological and induced neuronal death are not affected in NSE‐bax transgenic mice
TLDR
In the model system, Bax overexpression did not appear to influence the in vitro survival of sensory neurons isolated from dorsal root ganglia after nerve grwoth factor (NFG) deprivation or the apoptotic death of motor neurons following axotomy.
Apoptosis and Its Relation to the Cell Cycle in the Developing Cerebral Cortex
TLDR
It is concluded that apoptosis is prominent in the proliferating neuroepithelium of the developing rat cerebral cortex and that it is related to the progression of the cell cycle.
...
1
2
3
4
5
...