In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS

@article{Lossi2003InVC,
  title={In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS},
  author={Laura Lossi and Adalberto Merighi},
  journal={Progress in Neurobiology},
  year={2003},
  volume={69},
  pages={287-312}
}
Apoptosis has been recognized to be an essential process during neural development. It is generally assumed that about half of the neurons produced during neurogenesis die before completion of the central nervous system (CNS) maturation, and this process affects nearly all classes of neurons. In this review, we discuss the experimental data in vivo on naturally occurring neuronal death in normal, transgenic and mutant animals, with special attention to the cerebellum as a study model. The… 
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  • Biology, Medicine
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  • 2004
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Defining molecular mechanisms of programmed cell death is the necessary step preceding the adaptation of new protective and then, possibly, therapeutic strategies, and at present, the most promising are discoveries related to caspases, JNK, and GSK-3beta and their crucial role in stress-dependent and spontaneous apoptosis.
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This review focuses on how immature neurons survive during normal and impaired brain development, both in the embryonic/neonatal brain and in brain regions associated with adult neurogenesis, and emphasizes neuron type-specific mechanisms that help to survive for various types of immature neurons.
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Cerebellar neurons undergo different types of PCD and a Reelin deficiency affects the type and degree of neuronal death during postnatal development of the cerebellum, according to the type of death-triggering stimulus.
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