In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS

  title={In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS},
  author={L. Lossi and A. Merighi},
  journal={Progress in Neurobiology},
  • L. Lossi, A. Merighi
  • Published 2003
  • Biology, Medicine
  • Progress in Neurobiology
  • Apoptosis has been recognized to be an essential process during neural development. It is generally assumed that about half of the neurons produced during neurogenesis die before completion of the central nervous system (CNS) maturation, and this process affects nearly all classes of neurons. In this review, we discuss the experimental data in vivo on naturally occurring neuronal death in normal, transgenic and mutant animals, with special attention to the cerebellum as a study model. The… CONTINUE READING
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