In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS
@article{Lossi2003InVC, title={In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS}, author={Laura Lossi and Adalberto Merighi}, journal={Progress in Neurobiology}, year={2003}, volume={69}, pages={287-312} }
155 Citations
Molecular morphology of neuronal apoptosis: Analysis of caspase 3 activation during postnatal development of mouse cerebellar cortex
- Biology, ChemistryJournal of Molecular Histology
- 2004
Data obtained from cerebellar cortex can be generalized to outline a more comprehensive picture of the cellular and molecular mechanisms of neuronal death not only in development, but also in a number of pathological conditions leading to neuronal loss.
Neuronal cell death: an overview of its different forms in central and peripheral neurons.
- BiologyMethods in molecular biology
- 2015
The main histological and ultrastructural features of the different types of cell death in neurons are described and related to the cellular pathways that are specifically activated in any of these types of PCD.
Apoptosis of the cerebellar neurons.
- BiologyHistology and histopathology
- 2008
This review examines the existing evidence about the two waves of apoptotic cell death that affect the different types of cerebellar neurons in normal development and certain pathological conditions.
Caspase-3 Mediated Cell Death in the Normal Development of the Mammalian Cerebellum
- BiologyInternational journal of molecular sciences
- 2018
Among the different types of neurons and glia in cerebellum, there is ample evidence for an intervention of caspase-3 in the regulation of NOND of the post-mitotic cerebellar granule cells and Purkinje neurons, as a consequence of failure to establish proper synaptic contacts with target (secondary cell death).
Cell death in early neural life.
- BiologyBirth defects research. Part C, Embryo today : reviews
- 2005
Observations on cell death in the early, proliferating stages of vertebrate neural development in mice and complementary in vivo approaches in other vertebrates are covered.
Essential Role for Survivin in Early Brain Development
- BiologyThe Journal of Neuroscience
- 2005
This study is the first to solidify a role for survivin as an antiapoptotic protein during normal neuronal development in vivo, and may impact on the understanding of neural repair, neural development, and neurodegenerative diseases.
Apoptosis: a key in neurodegenerative disorders.
- Biology, PsychologyCurrent neurovascular research
- 2004
Current concepts salient to understanding the apoptosis death program, the mediators and control of cellular apoptosis, and the relationship between aberrant apoptosis and genesis of neurodegenerative disorders are focused on.
Apoptosis in the central nervous system: Mechanisms and protective strategies.
- BiologyPolish journal of pharmacology
- 2004
Defining molecular mechanisms of programmed cell death is the necessary step preceding the adaptation of new protective and then, possibly, therapeutic strategies, and at present, the most promising are discoveries related to caspases, JNK, and GSK-3beta and their crucial role in stress-dependent and spontaneous apoptosis.
Neuronal survival in the brain: neuron type-specific mechanisms
- Biology, PsychologyCell death & disease
- 2017
This review focuses on how immature neurons survive during normal and impaired brain development, both in the embryonic/neonatal brain and in brain regions associated with adult neurogenesis, and emphasizes neuron type-specific mechanisms that help to survive for various types of immature neurons.
Cell death and neurodegeneration in the postnatal development of cerebellar vermis in normal and Reeler mice.
- BiologyAnnals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
- 2016
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