In vivo cancer targeting and imaging with semiconductor quantum dots

@article{Gao2004InVC,
  title={In vivo cancer targeting and imaging with semiconductor quantum dots},
  author={Xiaohu Gao and Yuanyuan Cui and Richard M. Levenson and Leland W K Chung and Shuming Nie},
  journal={Nature Biotechnology},
  year={2004},
  volume={22},
  pages={969-976}
}
We describe the development of multifunctional nanoparticle probes based on semiconductor quantum dots (QDs) for cancer targeting and imaging in living animals. [] Key Method The structural design involves encapsulating luminescent QDs with an ABC triblock copolymer and linking this amphiphilic polymer to tumor-targeting ligands and drug-delivery functionalities. In vivo targeting studies of human prostate cancer growing in nude mice indicate that the QD probes accumulate at tumors both by the enhanced…
Multifunctional quantum dots for cellular and molecular imaging
  • Xiaohu Gao
  • Biology, Chemistry
    2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • 2007
TLDR
In vivo targeting studies of human prostate cancer growing in nude mice indicate that the QD probes can be delivered to tumor sites by both enhanced permeation and retention and by antibody binding to cancer-specific cell surface biomarkers.
Quantum dots for in vivo molecular and cellular imaging.
TLDR
It is suggested that QD probes and spectral imaging can be combined for multiplexed imaging and detection of genes, proteins, and small-molecule drugs in single living cells, and that this imaging modality can be adopted for real-time visualization of cancer cell metastasis in live animals.
In vivo molecular and cellular imaging with quantum dots.
Quantum dots for cancer molecular imaging.
  • Xiaohu Gao, S. Dave
  • Biology, Chemistry
    Advances in experimental medicine and biology
  • 2007
TLDR
Bioconjugated QDs have raised new possibilities for ultrasensitive and multiplexed imaging of molecular targets in living cells and animal models and are most promising for improving the sensitivity of molecular imaging and quantitative cellular analysis.
Molecular profiling of single cancer cells and clinical tissue specimens with semiconductor quantum dots
TLDR
Recent developments in bioaffinity QD probes and their applications in molecular profiling of individual cancer cells and clinical tissue specimens are discussed.
Quantum Dot Nanotechnology for Prostate Cancer Research
TLDR
Bioconjugated QDs have raised new possibilities for ultrasensitive and multiplexed imaging of molecular targets in living cells, animal models, and, possibly, in human patients.
Targeted tumor cell internalization and imaging of multifunctional quantum dot-conjugated immunoliposomes in vitro and in vivo.
TLDR
The synthesis, biophysical characterization, tumor cell-selective internalization, and anticancer drug delivery of QD-conjugated immunoliposome-based nanoparticles (QD-ILs) are described to incorporate the unique optical properties of luminescent quantum dots into immunolIPosomes for cancer diagnosis and treatment.
Bioconjugated quantum dots for in vivo molecular and cellular imaging.
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