In vivo cancer targeting and imaging with semiconductor quantum dots

@article{Gao2004InVC,
  title={In vivo cancer targeting and imaging with semiconductor quantum dots},
  author={X. Gao and Yuanyuan Cui and R. Levenson and L. Chung and S. Nie},
  journal={Nature Biotechnology},
  year={2004},
  volume={22},
  pages={969-976}
}
We describe the development of multifunctional nanoparticle probes based on semiconductor quantum dots (QDs) for cancer targeting and imaging in living animals. [...] Key Method The structural design involves encapsulating luminescent QDs with an ABC triblock copolymer and linking this amphiphilic polymer to tumor-targeting ligands and drug-delivery functionalities. In vivo targeting studies of human prostate cancer growing in nude mice indicate that the QD probes accumulate at tumors both by the enhanced…Expand
4,045 Citations
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