In vivo cancer imaging by poly(ethylene glycol)-b-poly(ɛ-caprolactone) micelles containing a near-infrared probe.

@article{Cho2012InVC,
  title={In vivo cancer imaging by poly(ethylene glycol)-b-poly(ɛ-caprolactone) micelles containing a near-infrared probe.},
  author={Hyunah Cho and Guilherme L. Indig and Jamey P. Weichert and Ho-Chul Shin and Glen S. Kwon},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  year={2012},
  volume={8 2},
  pages={
          228-36
        }
}
UNLABELLED Noninvasive near-infrared (NIR) fluorescence imaging is a promising technique for the intraoperative assessment of solid tumor removal. We incorporated a lipophilic NIR probe, 1,1'-dioctadecyltetramethyl indotricarbocyanine iodide (DiR), in poly(ethylene glycol)-b-poly(ɛ-caprolactone) (PEG-b-PCL) micelles, resulting in DiR solubilization in water, occupying nanoscopic PEG-b-PCL micelles. DiR in a self-quenched or nonquenched state showed different kinetics of release from PEG-b-PCL… CONTINUE READING

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