In vivo bone formation by human bone marrow stromal cells: effect of carrier particle size and shape.

@article{Mankani2001InVB,
  title={In vivo bone formation by human bone marrow stromal cells: effect of carrier particle size and shape.},
  author={Mahesh H. Mankani and Sergei Kuznetsov and Ben Fowler and Albert Kingman and Pamela Robey},
  journal={Biotechnology and bioengineering},
  year={2001},
  volume={72 1},
  pages={96-107}
}
Successful closure of bone defects in patients remains an active area of basic and clinical research. A novel and promising approach is the transplantation of human bone marrow stromal cells (BMSCs), which have been shown to possess a significant osteogenic potential. The extent and quality of bone formation by transplanted human BMSCs strongly depends on the carrier matrix with which cells are transplanted; to date, hydroxyapatite/tricalcium phosphate (HA/TCP) supports far more osteogenesis… CONTINUE READING

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