In vivo bioluminescence imaging reveals redox-regulated activator protein-1 activation in paraventricular nucleus of mice with renovascular hypertension.

@article{Burmeister2011InVB,
  title={In vivo bioluminescence imaging reveals redox-regulated activator protein-1 activation in paraventricular nucleus of mice with renovascular hypertension.},
  author={Melissa A Burmeister and Colin N Young and Valdir de Andrade Braga and Scott D Butler and Ram V. Sharma and Robin L. Davisson},
  journal={Hypertension},
  year={2011},
  volume={57 2},
  pages={289-97}
}
Renovascular hypertension in mice is characterized by an elevation in hypothalamic angiotensin II levels. The paraventricular nucleus (PVN) is a major cardioregulatory site implicated in the neurogenic component of renovascular hypertension. Increased superoxide (O(2)(-·)) production in the PVN is involved in angiotensin II-dependent neurocardiovascular diseases such as hypertension and heart failure. Here, we tested the hypothesis that excessive O(2)(-·) production and activation of the redox… CONTINUE READING
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  • P Sinnayah, E Lazartigues, K Sakai, RV Sharma, CD Sigmund, RL Davisson
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