In vivo biodistribution and pharmacokinetics of silica nanoparticles as a function of geometry, porosity and surface characteristics.

@article{Yu2012InVB,
  title={In vivo biodistribution and pharmacokinetics of silica nanoparticles as a function of geometry, porosity and surface characteristics.},
  author={Tian Yu and Dallin Hubbard and Abhijit Ray and Hamidreza Ghandehari},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2012},
  volume={163 1},
  pages={46-54}
}
The in vivo biodistribution and pharmacokinetics of silica nanoparticles (SiO(2)) with systematically varied geometries, porosities, and surface characteristics were investigated in immune-competent CD-1 mice via the intravenous injection. The nanoparticles were taken up extensively by the liver and spleen. Mesoporous SiO(2) exhibited higher accumulation in the lung than nonporous SiO(2) of similar size. This accumulation was reduced by primary amine modification of the nanoparticles. High… CONTINUE READING