In vivo benzodiazepine receptor occupancy by CL 218,872 visualized by positron emission tomography in the brain of the living baboon: modulation by GABAergic transmission and relation with anticonvulsant activity

@article{Sayette1991InVB,
  title={In vivo benzodiazepine receptor occupancy by CL 218,872 visualized by positron emission tomography in the brain of the living baboon: modulation by GABAergic transmission and relation with anticonvulsant activity},
  author={V. de la Sayette and C. Chavoix and Emmanuel Brouillet and Philippe Hantraye and Masanari Kunimoto and M. Khalili-Varasteh and Bernard Guibert and C. Prenant and Mariannick Mazi{\'e}re},
  journal={Experimental Brain Research},
  year={1991},
  volume={83},
  pages={397-402}
}
In vivo benzodiazepine receptor occupancy by increasing doses of CL 218,872 has been evaluated in the baboon Papio papio, using (11C) RO 15-1788 as specific radioligand and positron emission tomography as external detection system. Although BZR heterogeneity has been previously demonstrated in the brain of the living baboon using PET, we did not observe in our studies that CL 218,872 interacts preferentially with one of the BZR subtypes. The monophasic pattern of the dose dependent CL 218,872… CONTINUE READING

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