In vivo atherosclerotic plaque characterization using magnetic susceptibility distinguishes symptom-producing plaques.

@article{Raman2008InVA,
  title={In vivo atherosclerotic plaque characterization using magnetic susceptibility distinguishes symptom-producing plaques.},
  author={Subha V. Raman and Marshall W. Winner and Tam Tran and Murugesan Velayutham and Orlando P. Simonetti and Peter B. Baker and John W. Olesik and Beth McCarthy and Amy K. Ferketich and Jay L. Zweier},
  journal={JACC. Cardiovascular imaging},
  year={2008},
  volume={1 1},
  pages={49-57}
}
OBJECTIVES We investigated the role of iron deposition in atherosclerotic plaque instability using a novel approach of in vivo plaque characterization by a noninvasive, noncontrast magnetic resonance-based T2* measurement. This approach was validated using ex vivo plaque analyses to establish that T2* accurately reflects intraplaque iron composition. BACKGROUND Iron catalyzes free radical production, a key step for lipid peroxidation and atherosclerosis development. The parameter T2* measures… CONTINUE READING

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