In vivo aspects of protein folding and quality control

@article{Balchin2016InVA,
  title={In vivo aspects of protein folding and quality control},
  author={David Balchin and Manajit Hayer-Hartl and F. Ulrich Hartl},
  journal={Science},
  year={2016},
  volume={353}
}
  • David Balchin, Manajit Hayer-Hartl, F. Ulrich Hartl
  • Published 2016
  • Medicine, Biology
  • Science
  • BACKGROUND Proteins are synthesized on ribosomes as linear chains of amino acids and must fold into unique three-dimensional structures to fulfill their biological functions. Protein folding is intrinsically error-prone, and how it is accomplished efficiently represents a problem of great biological and medical importance. During folding, the nascent polypeptide must navigate a complex energy landscape. As a result, misfolded molecules may accumulate that expose hydrophobic amino acid residues… CONTINUE READING

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