In vivo aspects of protein folding and quality control

@article{Balchin2016InVA,
  title={In vivo aspects of protein folding and quality control},
  author={D. Balchin and M. Hayer-Hartl and F. Hartl},
  journal={Science},
  year={2016},
  volume={353}
}
BACKGROUND Proteins are synthesized on ribosomes as linear chains of amino acids and must fold into unique three-dimensional structures to fulfill their biological functions. Protein folding is intrinsically error-prone, and how it is accomplished efficiently represents a problem of great biological and medical importance. During folding, the nascent polypeptide must navigate a complex energy landscape. As a result, misfolded molecules may accumulate that expose hydrophobic amino acid residues… Expand
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