In vivo application of mitochondrial pore inhibitors blocks the induction of apoptosis in axotomized neonatal facial motoneurons

@article{Vanderluit2003InVA,
  title={In vivo application of mitochondrial pore inhibitors blocks the induction of apoptosis in axotomized neonatal facial motoneurons},
  author={Jacqueline L. Vanderluit and Lowell T. McPhail and Karl John Lionel Fernandes and Nao Rei Kobayashi and Wolfram Tetzlaff},
  journal={Cell Death and Differentiation},
  year={2003},
  volume={10},
  pages={969-976}
}
AbstractAxotomy induces apoptosis in motoneurons of neonatal rodents. To identify the key players in motoneuron apoptosis, we assessed the progression of apoptosis at 4 h intervals following facial motoneuron axotomy. The mitochondrial release of cytochrome c, caspase-3 activation and nuclear condensation were first observed in the motoneuron cell bodies 16 h postaxotomy. In vivo application of inhibitors of the mitochondrial permeability transition pore, Bongkrekic acid and cyclosporin A… CONTINUE READING
Highly Cited
This paper has 24 citations. REVIEW CITATIONS

References

Publications referenced by this paper.
Showing 1-10 of 58 references

Similar Papers

Loading similar papers…