In vivo antitumor efficacy of interleukin-21 in combination with chemotherapeutics.

Abstract

Interleukin-21 (IL-21) is a class I cytokine with antitumor properties due to enhanced proliferation and effector function of CD8(+) T cells and natural killer (NK) cells. Here we have explored the magnitude and time-course of cytostatics-induced lymphopenia in mice and investigated whether treatment with cytostatics influences the antitumor effect of IL-21… (More)
DOI: 10.1016/j.cyto.2009.07.039

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