In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor.

@article{Fang2003InVA,
  title={In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor.},
  author={Jun Fang and Tomohiro Sawa and Takaaki Akaike and Teruo Akuta and Sanjeeb Kumar Sahoo and Greish Khaled and Akinobu Hamada and Hiroshi Maeda},
  journal={Cancer research},
  year={2003},
  volume={63 13},
  pages={3567-74}
}
High expression of the inducible isoform of heme oxygenase (HO-1) is now well known in solid tumors in humans and experimental animal models. We reported previously that HO-1 may be involved in tumor growth (Tanaka et al., Br. J. Cancer, 88: 902-909, 2003), in that inhibition of HO activity in tumors by using zinc protoporphyrin (ZnPP) significantly reduced tumor growth in a rat model. We demonstrate here that poly(ethylene glycol)-conjugated ZnPP (PEG-ZnPP), a water-soluble derivative of ZnPP… CONTINUE READING