In vivo antitumor activity of camptothecin incorporated in liposomes formulated with an artificial lipid and human serum albumin.

Abstract

Camptothecin (CPT) is a strong antitumor agent, but its use limited by its low solubility and the instability of the active lactone form. To overcome these difficulties, liposomes incorporating CPT (CPT liposomes) were designed and tested. CPT liposomes were formulated by the addition of 3,5-bis(dodecyloxy)benzoic acid (DB) to polyethylene glycol-containing… (More)
DOI: 10.1016/j.jconrel.2008.02.005

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